Nitric oxide-matrix metaloproteinase-9 interactions: Biological and pharmacological significance
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چکیده
منابع مشابه
Nitric oxide-matrix metaloproteinase-9 interactions: biological and pharmacological significance--NO and MMP-9 interactions.
Nitric oxide (NO) and matrix metalloproteinase 9 (MMP-9) levels are found to increase in inflammation states and in cancer, and their levels may be reciprocally modulated. Understanding interactions between NO and MMP-9 is of biological and pharmacological relevance and may prove crucial in designing new therapeutics. The reciprocal interaction between NO and MMP-9 have been studied for nearly ...
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The recent discovery that mammalian cells can synthesize nitric oxide coincided with the identification of this simple gas as a factor involved in cellular communication. Nitric oxide has now been shown to be derived from L-arginine in macrophages, endothelial cells and possibly other cell types. Its physiological role in macrophages may be as a cytotoxic agent. However, nitric oxide produced b...
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Gow, Andrew J., Christiana R. Farkouh, David A. Munson, Michael A. Posencheg, and Harry Ischiropoulos. Biological significance of nitric oxidemediated protein modifications. Am J Physiol Lung Cell Mol Physiol 287: L262– L268, 2004; 10.1152/ajplung.00295.2003.—Nitric oxide (NO), despite an apparently simple diatomic structure, has a wide variety of functions in both physiology and pathology and ...
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The vascular endothelium synthesizes nitric oxide (NO) from the terminal guanidino nitrogen atom( s) of L-arginine. NO accounts for the biological actions of endotheliumderived relaxing factor (EDRF). It is becoming apparent that the synthesis of NO from L-arginine not only explains endothelium-dependent vascular relaxation, but is a widespread mechanism for the regulation of cell function and ...
متن کاملBiological significance of nitric oxide-mediated protein modifications.
Nitric oxide (NO), despite an apparently simple diatomic structure, has a wide variety of functions in both physiology and pathology and within every major organ system. It has become an increasingly important scientific challenge to decipher how this wide range of activity is achieved. To this end a number of investigators have begun to explore how NO-mediated posttranslational modifications o...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2014
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2013.12.006